Our research

Research at the Institute of Tissue Medicine and Pathology deals with the development, diagnosis and treatment of diseases. Immune pathologies, inflammatory diseases and tumor biology are the current research interests. Ex vivo studies of human tissue samples and the use of experimental in vitro and in vivo model systems are used to answer our research questions.


Best Poster Award ELCC 2023

Philipp Zens received the Best Poster Award in the category of pathology/tumor biology during the European Lung Cancer Congress 2023 in Copenhagen. The presented results are the next pieces of the multicentric project (collaboration with Sabina Berezowska, CHUV) focusing on the molecular characterization of paired primary lung carcinoma and brain metastases. In concordance to the genomic characterization the MAPK-pathway popped up as the most differentially methylated pathway. Additionally, we could cluster the cohort in a brain metastasis specific, primary lung cancer specific and mixed group of samples.

First and third price for best oral presentation at ENETs Annual Conference 2022

Ilaria Marinoni was awarded with the first price for the best oral presentation of her project "(Epi) genetic progression steps in alpha-lineage MEN1-DAXX/ATRX mutated Pancreatic Neuroendocrine Tumors (PanNET)" at the 1st International NET forum.
Simon April was awarded with the third price for the best oral presentation on his PhD project "Patient-derived Tumoroids phenocopy original GEP-NENs & facilitate in vitro drug screening".

Travel Grant Award 10th French Autophagy Meeting (CFATG) 2022

French Autophagy Meeting (CFATG), 2022, Besançon

Jun Xu won a travel grant award to attend the annual meeting of the French Autophagy Society CFATG for his short oral presentation entitled "BNIP3L/NIX, a downstream effector of oncogene-induced cancer cell autophagy and invasion". His work describes how the oncogenic splice variant of the transcription factor DMTF1 activates autophagy in cancer cells paralleled by increased cellular migration.

Award for best research project & presentation at 15th Annual Meeting Swiss Stem Cell Network 2020

Featuring this year’s theme of “Organoid & other specialized cell cultures for clinical applications” Simon April-Monn (PhD Candidate, Gruppe Perren/Marinoni) was honored for his project on Patient-derived Islet-like Tumoroids and personalized medicine in PanNETs. The award was generously conferred by the co-hosts Bern Stem Cell Research and Regenerative Medicine (SCRM) & Bern Center for Precision Medicine (BCPM). 11.Dec.2020, Bern.

Posterprize of the German Society of Pathology 2020

Antonio Rodriguez (Resident, IFP and Research fellow, Rubin Lab) for the presentation of his research project «The genomic landscape of prostate cancer brain metastases»
104. Jahrestagung der Deutschen Gesellschaft für Pathologie (DGP), 4.-6. June 2020, Berlin

Posterprize of the Pathological Society of Great Britain & Ireland

Tereza Losmanová, for the presentation of her medical dissertation "Chaperone-mediated Autophagy Markers LAMP2A and HSC70 Are Independent Adverse Prognostic Markers in Primary Resected Squamous Cell Carcinomas of the Lung". Congratulations!
12th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland - 04.07.2019, Harrogate, UK

Dr. Lutz Zwillenberg-Preis 2017

At the 183rd Dies Academicus of the University of Bern the Dr. Lutz Zwillenberg Prize for an outstanding publication or PhD thesis in Biological Sciences was awarded to Daniel Zysset, PhD, for his work “TREM-1 links dyslipidemia to inflammation and lipid deposition in atherosclerosis”.

Prize for the best project by a medical student at the Day of Clinical Research 2017

Manuel Keller has received the prize for the best project by a medical student, for his medical dissertation project "Adverse prognostic value of PD-L1 expression in primary resected pulmonary squamous cell carcinomas and paired mediastinal lymph node metastases".
Day of Clinical Research 2017, Department for BioMedical Research (DBMR), 31.10.17, Bern.

Lutz Zwillenberg Prize Lukas Mager

In his PhD thesis entitled „Molecular Dissection of Inflammation-induced Immunopathologies“, Lukas Mager reveals an inflammatory mechanism that promotes blood as well as colon cancer. A molecular messenger, the so-called interleukin-33 (IL-33), plays an essential role in these diseases by activating immune cells and other cells in the tumor environment. This leads to the release of different growth factors triggering tumor growth. Therefore, IL-33 may represent a target for the therapy of these cancers.

Young Investigator Communication Workshop Award, WCLC 2016

Manuel Keller received the “Young Investigator Communication Workshop Award” at the 17th IASLC World Conference on Lung Cancer, 2016, Vienna, Austria, December 4-7th. He presented his MD dissertation work: “High PD-L1 expression is associated with worse prognosis in primary resected squamous cell carcinomas of the lung”. Congratulations!

Travel Grant, ELCC 2016 European Lung Cancer Conference

Sabina Berezowska, 13.-16.04.2016, Geneva; Autophagy in early stage NSCLC – prognostic significance of the autophagy markers p62 and LC3B. We are interested in investigating autophagy in non-small cell lung cancer. In this project, we assessed the prognostic role of autophagy in primary resected early-stage lung cancer.

2015 Tiniakos-Award for best contribution in GI-Pathology, 27th European Congress of Pathology

Eva Diamantis-Karamitopoulou, Indications for a strategic role of the stromal cells in the tumour progression of pancreatic cancer. Unsere Untersuchungen zeigen dass die Stromazellen in der Umgebung der Tumorbuds im Bereich der Invasionsfront des Pankreaskarzinoms regulieren das weitere Tumorwachstum durch genetische und epigenetische Veränderungen inklusiv Expression von microRNAs.

Virchows Archiv prize for the best paper of 2014

Tilman Rau, Defined morphological criteria allow reliable diagnosis of colorectal serrated polyps and predict polyp genetics


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